Contraindicated (one)pentobarbital will reduce the extent or outcome of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with sturdy CYP3A4 inducers is not really suggestedpentobarbital will decrease the level or impact of amlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use W